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Relationship among Location of T-Antigen-Induced DNA Distortion, Auxiliary Sequences, and DNA Replication Efficiency

T-antigen-induced DNA distortion was studied in a series of simian virus 40 (SV40) plasmid constructs whose relative replication efficiency ranges from 0.2 to 36. Bending was detected in the wild-type SV40 regulatory region consisting of three copies of the GC-rich 21-bp repeat but not in constructs...

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Main Authors: Okuley, Susan, Call, Mindy, Mitchell, Tara, Hu, Bugen, Woodworth, Mary E.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC228485/
https://ncbi.nlm.nih.gov/pubmed/12970450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.19.10651-10657.2003
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