Identification of Adenovirus (Ad) Penton Base Neutralizing Epitopes by Use of Sera from Patients Who Had Received Conditionally Replicative Ad (Addl1520) for Treatment of Liver Tumors

Sera from 17 patients with primary and secondary liver tumors who had been administered oncolytic adenovirus (Ad) mutant Addl1520 were analyzed for anti-Ad neutralization titers and antibodies to the Ad major capsid proteins hexon, penton base (Pb), and fiber. The antibodies recognized mainly confor...

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Main Authors: Hong, Saw See, Habib, Nagy A., Franqueville, Laure, Jensen, Steen, Boulanger, Pierre A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2003
Assuntos:
Gene Therapy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC228409/
https://ncbi.nlm.nih.gov/pubmed/12970421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.19.10366-10375.2003
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