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Peptide design by artificial neural networks and computer-based evolutionary search

A technique for systematic peptide variation by a combination of rational and evolutionary approaches is presented. The design scheme consists of five consecutive steps: (i) identification of a “seed peptide” with a desired activity, (ii) generation of variants selected from a physicochemical space...

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Detalhes bibliográficos
Main Authors: Schneider, Gisbert, Schrödl, Wieland, Wallukat, Gerd, Müller, Johannes, Nissen, Eberhard, Rönspeck, Wolfgang, Wrede, Paul, Kunze, Rudolf
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC22805/
https://ncbi.nlm.nih.gov/pubmed/9770460
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