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GroEL-GroES-mediated protein folding requires an intact central cavity

The chaperonin GroEL is an oligomeric double ring structure that, together with the cochaperonin GroES, assists protein folding. Biochemical analyses indicate that folding occurs in a cis ternary complex in which substrate is sequestered within the GroEL central cavity underneath GroES. Recently, ho...

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Detalhes bibliográficos
Main Authors: Wang, Jue D., Michelitsch, Melissa D., Weissman, Jonathan S.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC22802/
https://ncbi.nlm.nih.gov/pubmed/9770457
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