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Probing folding and fluorescence quenching in human γD crystallin Greek key domains using triple tryptophan mutant proteins

Human γD crystallin (HγD-Crys), a major component of the human eye lens, is a 173-residue, primarily β-sheet protein, associated with juvenile and mature-onset cataracts. HγD-Crys has four tryptophans, with two in each of the homologous Greek key domains, which are conserved throughout the γ-crystal...

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Bibliografske podrobnosti
Main Authors: Kosinski-Collins, Melissa S., Flaugh, Shannon L., King, Jonathan
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279819/
https://ncbi.nlm.nih.gov/pubmed/15273315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.04627004
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