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Influence of the N-terminal domain on the aggregation properties of the prion protein

Prion diseases appear to be caused by the aggregation of the cellular prion protein (PrP(C)) into an infectious form denoted PrP(Sc). The in vitro aggregation of the prion protein has been extensively investigated, yet many of these studies utilize truncated polypeptides. Because the C-terminal port...

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Hlavní autoři: Frankenfield, Kristen N., Powers, Evan T., Kelly, Jeffery W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279327/
https://ncbi.nlm.nih.gov/pubmed/16046631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051434005
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