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Positive selection acting on splicing motifs reflects compensatory evolution
We have used comparative genomics to characterize the evolutionary behavior of predicted splicing regulatory motifs. Using base substitution rates in intronic regions as a calibrator for neutral change, we found a strong avoidance of synonymous substitutions that disrupt predicted exonic splicing en...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cold Spring Harbor Laboratory Press
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2279241/ https://ncbi.nlm.nih.gov/pubmed/18204002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.070268.107 |
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