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Positive selection acting on splicing motifs reflects compensatory evolution
We have used comparative genomics to characterize the evolutionary behavior of predicted splicing regulatory motifs. Using base substitution rates in intronic regions as a calibrator for neutral change, we found a strong avoidance of synonymous substitutions that disrupt predicted exonic splicing en...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2279241/ https://ncbi.nlm.nih.gov/pubmed/18204002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.070268.107 |
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