Unique agonist-bound cannabinoid CB(1) receptor conformations indicate agonist specificity in signaling

Cannabinoid drugs differ in their rank order of potency to produce analgesia versus other central nervous system effects. We propose that these differences are due to unique agonist-bound cannabinoid CB(1) receptor conformations that exhibit different affinities for individual subsets of intracellul...

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Main Authors: Georgieva, Teodora, Devanathan, Savitha, Stropova, Dagmar, Park, Chad K., Salamon, Zdzislaw, Tollin, Gordon, Hruby, Victor J., Roeske, William R., Yamamura, Henry I., Varga, Eva
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279194/
https://ncbi.nlm.nih.gov/pubmed/18162180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2007.11.053
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