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Disruption of CFTR-Dependent Lipid Rafts Reduces Bacterial Levels and Corneal Disease in a Murine Model of Pseudomonas aeruginosa Keratitis

PURPOSE: Pseudomonas aeruginosa enters corneal epithelial cells in vitro via membrane microdomains or lipid rafts. Bacterial entry, mediated by the cystic fibrosis transmembrane conductance regulator (CFTR), promotes infection and disease. This study was conducted to determine whether P. aeruginosa...

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Main Authors: Zaidi, Tanweer, Bajmoczi, Milan, Zaidi, Tauqeer, Golan, David E., Pier, Gerald B.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279184/
https://ncbi.nlm.nih.gov/pubmed/18326723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.07-0993
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