Luminal Ca(2+) Regulation of Single Cardiac Ryanodine Receptors: Insights Provided by Calsequestrin and its Mutants

The luminal Ca2+ regulation of cardiac ryanodine receptor (RyR2) was explored at the single channel level. The luminal Ca2+ and Mg2+ sensitivity of single CSQ2-stripped and CSQ2-associated RyR2 channels was defined. Action of wild-type CSQ2 and of two mutant CSQ2s (R33Q and L167H) was also compared....

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Main Authors: Qin, Jia, Valle, Giorgia, Nani, Alma, Nori, Alessandra, Rizzi, Nicoletta, Priori, Silvia G., Volpe, Pompeo, Fill, Michael
פורמט: Artigo
שפה:Inglês
יצא לאור: The Rockefeller University Press 2008
נושאים:
Articles
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279168/
https://ncbi.nlm.nih.gov/pubmed/18347081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200709907
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