Mutation K448E in the external loop 5 of rat GABA transporter rGAT1 induces pH sensitivity and alters substrate interactions

1. The effect of the mutation K448E in the rat GABA transporter rGAT1 was studied using heterologous expression in Xenopus oocytes and voltage clamp. 2. At neutral pH, the transport-associated current vs. voltage (I–V) relationship of the mutated transporter was different from wild-type, and the pre...

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Detalles Bibliográficos
Main Authors: Forlani, Greta, Bossi, Elena, Ghirardelli, Roberta, Giovannardi, Stefano, Binda, Francesca, Bonadiman, Lorena, Ielmini, Lorena, Peres, Antonio
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2001
Assuntos:
Research Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278863/
https://ncbi.nlm.nih.gov/pubmed/11600683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2001.0479c.xd
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