Mutation K448E in the external loop 5 of rat GABA transporter rGAT1 induces pH sensitivity and alters substrate interactions

1. The effect of the mutation K448E in the rat GABA transporter rGAT1 was studied using heterologous expression in Xenopus oocytes and voltage clamp. 2. At neutral pH, the transport-associated current vs. voltage (I–V) relationship of the mutated transporter was different from wild-type, and the pre...

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Bibliographic Details
Main Authors: Forlani, Greta, Bossi, Elena, Ghirardelli, Roberta, Giovannardi, Stefano, Binda, Francesca, Bonadiman, Lorena, Ielmini, Lorena, Peres, Antonio
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2001
Subjects:
Research Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278863/
https://ncbi.nlm.nih.gov/pubmed/11600683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2001.0479c.xd
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