Cyclic GMP regulation of the L-type Ca(2+) channel current in human atrial myocytes

1. The regulation of the L-type Ca(2+) current (I(Ca)) by intracellular cGMP was investigated in human atrial myocytes using the whole-cell patch-clamp technique. 2. Intracellular application of 0.5 μm cGMP produced a strong stimulation of basal I(Ca) (+64 ± 5%, n = 60), whereas a 10-fold higher cGM...

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Autores principales: Vandecasteele, Grégoire, Verde, Ignacio, Rücker-Martin, Catherine, Donzeau-Gouge, Patrick, Fischmeister, Rodolphe
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2001
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278627/
https://ncbi.nlm.nih.gov/pubmed/11389195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2001.0329a.x
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