G protein-mediated inhibitory effect of a nitric oxide donor on the L-type Ca(2+) current in rat ventricular myocytes

1. The role of the cGMP pathway in the modulation of the cardiac L-type Ca(2+) current (I(Ca,L)) by nitric oxide (NO) was examined in rat ventricular myocytes. 2. The NO donors DEANO, SIN-1, SNP, SNAP and GSNO had no significant effects on basal I(Ca,L). However, DEANO (100 μM) inhibited I(Ca,L) aft...

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Detalles Bibliográficos
Main Authors: Abi-Gerges, Najah, Fischmeister, Rodolphe, Méry, Pierre-François
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2001
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278448/
https://ncbi.nlm.nih.gov/pubmed/11179396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2001.0117j.x
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