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Microbial carbohydrate depolymerization by antigen-presenting cells: Deamination prior to presentation by the MHCII pathway

After uptake by the endosome of an antigen-presenting cell (APC), exogenous proteins are known to be degraded into peptides by protease digestion. Here, we report the mechanism by which pure carbohydrates can be depolymerized within APC endosomes/lysosomes by nitric oxide (NO)-derived reactive nitro...

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Autores principales: Duan, Jinyou, Avci, Fikri Y., Kasper, Dennis L.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278222/
https://ncbi.nlm.nih.gov/pubmed/18381820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800974105
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