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Homozygous deletion of glycogen synthase kinase 3β bypasses senescence allowing Ras transformation of primary murine fibroblasts
In primary mammalian cells, expression of oncogenes such as activated Ras induces premature senescence rather than transformation. We show that homozygous deletion of glycogen synthase kinase (GSK) 3β (GSK3β(−/−)) bypasses senescence induced by mutant Ras(V12) allowing primary mouse embryo fibroblas...
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| Hoofdauteurs: | , , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2008
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2278194/ https://ncbi.nlm.nih.gov/pubmed/18367674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704242105 |
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