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Homozygous deletion of glycogen synthase kinase 3β bypasses senescence allowing Ras transformation of primary murine fibroblasts
In primary mammalian cells, expression of oncogenes such as activated Ras induces premature senescence rather than transformation. We show that homozygous deletion of glycogen synthase kinase (GSK) 3β (GSK3β(−/−)) bypasses senescence induced by mutant Ras(V12) allowing primary mouse embryo fibroblas...
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| Main Authors: | , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
2008
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2278194/ https://ncbi.nlm.nih.gov/pubmed/18367674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704242105 |
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