Homozygous deletion of glycogen synthase kinase 3β bypasses senescence allowing Ras transformation of primary murine fibroblasts

In primary mammalian cells, expression of oncogenes such as activated Ras induces premature senescence rather than transformation. We show that homozygous deletion of glycogen synthase kinase (GSK) 3β (GSK3β(−/−)) bypasses senescence induced by mutant Ras(V12) allowing primary mouse embryo fibroblas...

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Detalhes bibliográficos
Main Authors: Liu, Shuying, Fang, Xianjun, Hall, Hassan, Yu, Shuangxing, Smith, Debra, Lu, Zhimin, Fang, Dexing, Liu, Jinsong, Stephens, L. Clifton, Woodgett, James R., Mills, Gordon B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278194/
https://ncbi.nlm.nih.gov/pubmed/18367674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704242105
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