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Homozygous deletion of glycogen synthase kinase 3β bypasses senescence allowing Ras transformation of primary murine fibroblasts

In primary mammalian cells, expression of oncogenes such as activated Ras induces premature senescence rather than transformation. We show that homozygous deletion of glycogen synthase kinase (GSK) 3β (GSK3β(−/−)) bypasses senescence induced by mutant Ras(V12) allowing primary mouse embryo fibroblas...

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מידע ביבליוגרפי
Main Authors: Liu, Shuying, Fang, Xianjun, Hall, Hassan, Yu, Shuangxing, Smith, Debra, Lu, Zhimin, Fang, Dexing, Liu, Jinsong, Stephens, L. Clifton, Woodgett, James R., Mills, Gordon B.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278194/
https://ncbi.nlm.nih.gov/pubmed/18367674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704242105
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