Convergence of Multiple Signaling Cascades at Glycogen Synthase Kinase 3: Edg Receptor-Mediated Phosphorylation and Inactivation by Lysophosphatidic Acid through a Protein Kinase C-Dependent Intracellular Pathway

Lysophosphatidic acid (LPA) is a natural phospholipid with multiple biological functions. We show here that LPA induces phosphorylation and inactivation of glycogen synthase kinase 3 (GSK-3), a multifunctional serine/threonine kinase. The effect of LPA can be reconstituted by expression of Edg-4 or...

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Detalhes bibliográficos
Main Authors: Fang, Xianjun, Yu, Shuangxing, Tanyi, Janos L., Lu, Yiling, Woodgett, James R., Mills, Gordon B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133668/
https://ncbi.nlm.nih.gov/pubmed/11884598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.7.2099-2110.2002
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