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Liver proteomics for therapeutic drug discovery: inhibition of the cyclophilin receptor CD147 attenuates sepsis-induced acute renal failure

OBJECTIVE: Sepsis-induced multi-organ failure continues to have a high mortality. The liver is an organ central to the disease pathogenesis. The objective of this study was to identify the liver proteins that change in abundance with sepsis and, therefore, identify new drug targets. DESIGN: Proteomi...

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Detalhes bibliográficos
Main Authors: Dear, James W., Leelahavanichkul, Asada, Aponte, Angel, Hu, Xuzhen, Constant, Stephanie L., Hewitt, Stephen M., Yuen, Peter S.T., Star, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278121/
https://ncbi.nlm.nih.gov/pubmed/17944020
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