The role of transmembrane domain 2 in cation transport by the Na–K–Cl cotransporter
The human and shark Na–K–Cl cotransporters (NKCC), although 74% identical in amino acid sequence, exhibit marked differences in ion transport and bumetanide binding. We have utilized shark–human chimeras of NKCC1 to search for regions that confer the kinetic differences. Two chimeras (hs3.1 and its...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1998
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22778/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9618559/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.12.7179 |
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