Safety and Immunogenicity of a Malaria Vaccine, Plasmodium falciparum AMA-1/MSP-1 Chimeric Protein Formulated in Montanide ISA 720 in Healthy Adults

BACKGROUND: The P. falciparum chimeric protein 2.9 (PfCP-2.9) consisting of the sequences of MSP1-19 and AMA-1 (III) is a malaria vaccine candidate that was found to induce inhibitory antibodies in rabbits and monkeys. This was a phase I randomized, single-blind, placebo-controlled, dose-escalation...

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Autori principali: Hu, Jinhong, Chen, Zhihui, Gu, Jun, Wan, Mobin, Shen, Qian, Kieny, Marie-Paule, He, Jia, Li, Zhen, Zhang, Qingfeng, Reed, Zarifah Hussain, Zhu, Yongmei, Li, Wenjie, Cao, Yang, Qu, Li, Cao, Zhifang, Wang, Qiang, Liu, Haitao, Pan, Xuegong, Huang, Xiudong, Zhang, Dongmei, Xue, Xiangyang, Pan, Weiqing
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276862/
https://ncbi.nlm.nih.gov/pubmed/18398475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001952
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