Safety and Immunogenicity of a Recombinant Plasmodium falciparum AMA1 Malaria Vaccine Adjuvanted with Alhydrogel™, Montanide ISA 720 or AS02

BACKGROUND: Plasmodium falciparum Apical Membrane Antigen 1 (PfAMA1) is a candidate vaccine antigen expressed by merozoites and sporozoites. It plays a key role in red blood cell and hepatocyte invasion that can be blocked by antibodies. METHODOLOGY/PRINCIPAL FINDINGS: We assessed the safety and imm...

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Detalhes bibliográficos
Main Authors: Roestenberg, Meta, Remarque, Ed, de Jonge, Erik, Hermsen, Rob, Blythman, Hildur, Leroy, Odile, Imoukhuede, Egeruan, Jepsen, Soren, Ofori-Anyinam, Opokua, Faber, Bart, Kocken, Clemens H. M., Arnold, Miranda, Walraven, Vanessa, Teelen, Karina, Roeffen, Will, de Mast, Quirijn, Ballou, W. Ripley, Cohen, Joe, Dubois, Marie Claude, Ascarateil, Stéphane, van der Ven, Andre, Thomas, Alan, Sauerwein, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2602972/
https://ncbi.nlm.nih.gov/pubmed/19093004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003960
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