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An Intracellular Loop (IL2) Residue Confers Different Basal Constitutive Activities to the Human Lutropin Receptor and Human Thyrotropin Receptor through Structural Communication between IL2 and Helix 6, via Helix 3

The human lutropin receptor (hLHR) and human TSH receptor (hTSHR) are G protein-coupled receptors that play key roles in reproductive and thyroid physiology, respectively. We show using a quantitative assessment of cAMP production as a function of cell surface receptor expression that the hTSHR poss...

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Autors principals: Feng, Xiuyan, Müller, Thomas, Mizrachi, Dario, Fanelli, Francesca, Segaloff, Deborah L.
Format: Artigo
Idioma:Inglês
Publicat: The Endocrine Society 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276707/
https://ncbi.nlm.nih.gov/pubmed/18162522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2007-1341
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