CONFORMATIONAL STABILITY OF PrP AMYLOID FIBRILS CONTOLS THEIR SMALLEST POSSIBLE FRAGMENT SIZE

Fibril fragmentation is considered to be an essential step in prion replication. Recent studies have revealed a strong correlation between the incubation period to prion disease and conformational stability of synthetic prions. To gain insight into the molecular mechanism that accounts for this corr...

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Bibliographische Detailangaben
Hauptverfasser: Sun, Ying, Makarava, Natallia, Lee, Cheng-I, Laksanalamai, Pongpan, Robb, Frank T., Baskakov, Ilia V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276463/
https://ncbi.nlm.nih.gov/pubmed/18206163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.12.053
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