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CONFORMATIONAL STABILITY OF PrP AMYLOID FIBRILS CONTOLS THEIR SMALLEST POSSIBLE FRAGMENT SIZE
Fibril fragmentation is considered to be an essential step in prion replication. Recent studies have revealed a strong correlation between the incubation period to prion disease and conformational stability of synthetic prions. To gain insight into the molecular mechanism that accounts for this corr...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2276463/ https://ncbi.nlm.nih.gov/pubmed/18206163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.12.053 |
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