A Key Claudin Extracellular Loop Domain is Critical for Epithelial Barrier Integrity

Intercellular tight junctions (TJs) regulate epithelial barrier properties. Claudins are major structural constituents of TJs and belong to a large family of tetra-spanning membrane proteins that have two predicted extracellular loops (ELs). Given that claudin-1 is widely expressed in epithelia, we...

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Main Authors: Mrsny, Randall J., Brown, G. Thomas, Gerner-Smidt, Kirsten, Buret, Andre G., Meddings, Jon B., Quan, Clifford, Koval, Michael, Nusrat, Asma
格式: Artigo
語言:Inglês
出版: American Society for Investigative Pathology 2008
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Regular Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276422/
https://ncbi.nlm.nih.gov/pubmed/18349130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070698
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