Endothelin receptor antagonism prevents hypoxia-induced mortality and morbidity in a mouse model of sickle-cell disease

Patients with sickle-cell disease (SCD) suffer from tissue damage and life-threatening complications caused by vasoocclusive crisis (VOC). Endothelin receptors (ETRs) are mediators of one of the most potent vasoconstrictor pathways in mammals, but the relationship between vasoconstriction and VOC is...

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Detalhes bibliográficos
Main Authors: Sabaa, Nathalie, de Franceschi, Lucia, Bonnin, Philippe, Castier, Yves, Malpeli, Giorgio, Debbabi, Haythem, Galaup, Ariane, Maier-Redelsperger, Micheline, Vandermeersch, Sophie, Scarpa, Aldo, Janin, Anne, Levy, Bernard, Girot, Robert, Beuzard, Yves, Leboeuf, Christophe, Henri, Annie, Germain, Stéphane, Dussaule, Jean-Claude, Tharaux, Pierre-Louis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276396/
https://ncbi.nlm.nih.gov/pubmed/18382768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33308
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