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Betaine-Homocysteine S-Methyltransferase-2 Is an S-Methylmethionine-Homocysteine Methyltransferase

We demonstrate that purified recombinant human betainehomocysteine methyltransferase-2 (BHMT-2) is a zinc metalloenzyme that uses S-methylmethionine (SMM) as a methyl donor for the methylation of homocysteine. Unlike the highly homologous betaine-homocysteine methyltransferase (BHMT), BHMT-2 cannot...

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Autors principals: Szegedi, Sandra S., Castro, Carmen C., Koutmos, Markos, Garrow, Timothy A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276374/
https://ncbi.nlm.nih.gov/pubmed/18230605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710449200
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