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Conformation-dependent inactivation of human betaine-homocysteine S-methyltransferase by hydrogen peroxide in vitro

Betaine-homocysteine S-methyltransferase (BHMT) transfers a methyl group from betaine to Hcy to form DMG (dimethylglycine) and Met. The reaction is ordered Bi Bi; Hcy is the first substrate to bind and Met is the last product off. Using intrinsic tryptophan fluorescence [Castro, Gratson, Evans, Jira...

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Autors principals: Miller, Catherine M., Szegedi, Sandra S., Garrow, Timothy A.
Format: Artigo
Idioma:Inglês
Publicat: Portland Press Ltd. 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316282/
https://ncbi.nlm.nih.gov/pubmed/16038618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050356
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