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Human Macrophages Support Persistent Transcription From Unintegrated HIV-1 DNA
Retroviruses require integration of their RNA genomes for both stability and productive viral replication. In HIV infection of non-dividing, resting CD4 T cells, where integration is greatly impeded, the reverse transcribed HIV DNA has limited biological activity and a short half-life. In metabolica...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2276161/ https://ncbi.nlm.nih.gov/pubmed/18054979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2007.11.007 |
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