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Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK

Connective tissue growth factor (CTGF, CCN2) is overexpressed in pancreatic cancer. We mapped the minimal CCN2 promoter active in PANC-1 cells, a human pancreatic cancer cell line. Within this region, Sp1, BCE-1 and Ets elements were important for the activity of the CCN2 promoter. Constitutive hype...

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Detalhes bibliográficos
Main Authors: Pickles, Melissa, Leask, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275873/
https://ncbi.nlm.nih.gov/pubmed/18481199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-007-0008-9
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