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Impact of Hapten Presentation on Antibody Binding at Lipid Membrane Interfaces

We report the effects of ligand presentation on the binding of aqueous proteins to solid supported lipid bilayers. Specifically, we show that the equilibrium dissociation constant can be strongly affected by ligand lipophilicity and linker length/structure. The apparent equilibrium dissociation cons...

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Main Authors: Jung, Hyunsook, Yang, Tinglu, Lasagna, Mauricio D., Shi, Jinjun, Reinhart, Gregory D., Cremer, Paul S.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275692/
https://ncbi.nlm.nih.gov/pubmed/18199665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.115519
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