Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer

Although mutation of APC or CTNNB1 (β-catenin) is rare in breast cancer, activation of Wnt signalling is nonetheless thought to play an important role in breast tumorigenesis, and epigenetic silencing of Wnt antagonist genes, including the secreted frizzled-related protein (SFRP) and Dickkopf (DKK)...

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Main Authors: Suzuki, H, Toyota, M, Caraway, H, Gabrielson, E, Ohmura, T, Fujikane, T, Nishikawa, N, Sogabe, Y, Nojima, M, Sonoda, T, Mori, M, Hirata, K, Imai, K, Shinomura, Y, Baylin, S B, Tokino, T
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2008
Fag:
Genetics and Genomics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275475/
https://ncbi.nlm.nih.gov/pubmed/18283316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604259
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