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Enhanced antithrombotic effects of unfractionated heparin in rats after repeated oral doses and its relationship to endothelial heparin concentration
BACKGROUND AND PURPOSE: An oral, single dose of 7.5 mg kg(−1) of unfractionated heparin (UFH) reduces thrombosis by 50% in a rat model of venous thrombosis. As long-term use is required clinically, our objectives were to study the antithrombotic effects following repeated oral UFH administration. EX...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2275434/ https://ncbi.nlm.nih.gov/pubmed/18264127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.14 |
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