Enhanced antithrombotic effects of unfractionated heparin in rats after repeated oral doses and its relationship to endothelial heparin concentration

BACKGROUND AND PURPOSE: An oral, single dose of 7.5 mg kg(−1) of unfractionated heparin (UFH) reduces thrombosis by 50% in a rat model of venous thrombosis. As long-term use is required clinically, our objectives were to study the antithrombotic effects following repeated oral UFH administration. EX...

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Main Authors: Hiebert, L M, Ping, T, Wice, S M
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2008
נושאים:
Research Papers
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275434/
https://ncbi.nlm.nih.gov/pubmed/18264127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.14
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