Disruption of Growth Hormone Signaling Retards Prostate Carcinogenesis in the Probasin/TAg Rat

We asked whether down-regulation of GH signaling could block carcinogenesis in the Probasin/TAg rat, a model of aggressive prostate cancer. The Spontaneous Dwarf rat, which lacks GH due to a mutation (dr) in its GH gene, was crossed with the Probasin/TAg rat, which develops prostate carcinomas at 10...

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Main Authors: Wang, Zhuohua, Luque, Raul M., Kineman, Rhonda D., Ray, Vera H., Christov, Konstantin T., Lantvit, Daniel D., Shirai, Tomoyuki, Hedayat, Samad, Unterman, Terry G., Bosland, Maarten C., Prins, Gail S., Swanson, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado: The Endocrine Society 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275369/
https://ncbi.nlm.nih.gov/pubmed/18079205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2007-1410
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