Disruption of Growth Hormone Signaling Retards Prostate Carcinogenesis in the Probasin/TAg Rat

We asked whether down-regulation of GH signaling could block carcinogenesis in the Probasin/TAg rat, a model of aggressive prostate cancer. The Spontaneous Dwarf rat, which lacks GH due to a mutation (dr) in its GH gene, was crossed with the Probasin/TAg rat, which develops prostate carcinomas at 10...

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Главные авторы: Wang, Zhuohua, Luque, Raul M., Kineman, Rhonda D., Ray, Vera H., Christov, Konstantin T., Lantvit, Daniel D., Shirai, Tomoyuki, Hedayat, Samad, Unterman, Terry G., Bosland, Maarten C., Prins, Gail S., Swanson, Steven M.
Формат: Artigo
Язык:Inglês
Опубликовано: The Endocrine Society 2008
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275369/
https://ncbi.nlm.nih.gov/pubmed/18079205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2007-1410
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