Dehydroepiandrosterone Stimulates Endothelial Proliferation and Angiogenesis through Extracellular Signal-Regulated Kinase 1/2-Mediated Mechanisms

Dehydroepiandrosterone (DHEA) activates a plasma membrane receptor on vascular endothelial cells and phosphorylates ERK 1/2. We hypothesize that ERK1/2-dependent vascular endothelial proliferation underlies part of the beneficial vascular effect of DHEA. DHEA (0.1–10 nm) activated ERK1/2 in bovine a...

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Auteurs principaux: Liu, Dongmin, Iruthayanathan, Mary, Homan, Laurie L., Wang, Yiqiang, Yang, Lingling, Wang, Yao, Dillon, Joseph S.
Format: Artigo
Langue:Inglês
Publié: The Endocrine Society 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275364/
https://ncbi.nlm.nih.gov/pubmed/18079198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2007-1125
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