Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver

MicroRNA-122 (miR-122) is an abundant liver-specific miRNA, implicated in fatty acid and cholesterol metabolism as well as hepatitis C viral replication. Here, we report that a systemically administered 16-nt, unconjugated LNA (locked nucleic acid)-antimiR oligonucleotide complementary to the 5′ end...

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Detalhes bibliográficos
Main Authors: Elmén, Joacim, Lindow, Morten, Silahtaroglu, Asli, Bak, Mads, Christensen, Mette, Lind-Thomsen, Allan, Hedtjärn, Maj, Hansen, Jens Bo, Hansen, Henrik Frydenlund, Straarup, Ellen Marie, McCullagh, Keith, Kearney, Phil, Kauppinen, Sakari
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275095/
https://ncbi.nlm.nih.gov/pubmed/18158304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm1113
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