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Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse
Nucleophosmin (NPM1) gene has been heavily implicated in cancer pathogenesis both as a putative proto-oncogene and tumor suppressor gene. NPM1 is the most frequently mutated gene in acute myeloid leukemia (AML), while deletion of 5q, where NPM1 maps, is frequent in patients with myelodysplastic synd...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Hematology
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2275037/ https://ncbi.nlm.nih.gov/pubmed/18212245 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-098251 |
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