The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes

The V617F activating point mutation in Jak2 is associated with a proportion of myeloproliferative disorders. In normal hematopoietic cells, Jak2 signals only when associated with a growth factor receptor, such as the erythropoietin receptor (EpoR). We sought to identify the molecular requirements fo...

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Detalhes bibliográficos
Main Authors: Wernig, Gerlinde, Gonneville, Jeffrey R., Crowley, Brian J., Rodrigues, Margret S., Reddy, Mamatha M., Hudon, Heidi E., Walz, Christoph, Reiter, Andreas, Podar, Klaus, Royer, Yohan, Constantinescu, Stefan N., Tomasson, Michael H., Griffin, James D., Gilliland, D. Gary, Sattler, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275031/
https://ncbi.nlm.nih.gov/pubmed/18216297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-07-102186
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