HIF-1α regulates epithelial inflammation by cell autonomous NFκB activation and paracrine stromal remodeling

Hypoxia inducible factor-1 (HIF-1) is a master regulatory transcription factor controlling multiple cell-autonomous and non–cell-autonomous processes, such as metabolism, angiogenesis, matrix invasion, and cancer metastasis. Here we used a new line of transgenic mice with constitutive gain of HIF-1...

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Autors principals: Scortegagna, Marzia, Cataisson, Christophe, Martin, Rebecca J., Hicklin, Daniel J., Schreiber, Robert D., Yuspa, Stuart H., Arbeit, Jeffrey M.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2008
Matèries:
Chemokines, Cytokines, and Interleukins
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275004/
https://ncbi.nlm.nih.gov/pubmed/18199827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-10-115758
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