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Evidence that tRNA modifying enzymes are important in vivo targets for 5-fluorouracil in yeast
We have screened a collection of haploid yeast knockout strains for increased sensitivity to 5-fluorouracil (5-FU). A total of 138 5-FU sensitive strains were found. Mutants affecting rRNA and tRNA maturation were particularly sensitive to 5-FU, with the tRNA methylation mutant trm10 being the most...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2271368/ https://ncbi.nlm.nih.gov/pubmed/18314501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.966208 |
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