Crystal structure of enoyl–acyl carrier protein reductase (FabK) from Streptococcus pneumoniae reveals the binding mode of an inhibitor

Enoyl–acyl carrier protein (ACP) reductases are critical for bacterial type II fatty acid biosynthesis and thus are attractive targets for developing novel antibiotics. We determined the crystal structure of enoyl–ACP reductase (FabK) from Streptococcus pneumoniae at 1.7 Å resolution. There was one...

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Autores principales: Saito, Jun, Yamada, Mototsugu, Watanabe, Takashi, Iida, Maiko, Kitagawa, Hideo, Takahata, Sho, Ozawa, Tomohiro, Takeuchi, Yasuo, Ohsawa, Fukuichi
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2271168/
https://ncbi.nlm.nih.gov/pubmed/18305197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073288808
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