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Genome-Wide Prediction of SH2 Domain Targets Using Structural Information and the FoldX Algorithm
Current experiments likely cover only a fraction of all protein-protein interactions. Here, we developed a method to predict SH2-mediated protein-protein interactions using the structure of SH2-phosphopeptide complexes and the FoldX algorithm. We show that our approach performs similarly to experime...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2271153/ https://ncbi.nlm.nih.gov/pubmed/18389064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000052 |
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