Genome-Wide Prediction of SH2 Domain Targets Using Structural Information and the FoldX Algorithm

Current experiments likely cover only a fraction of all protein-protein interactions. Here, we developed a method to predict SH2-mediated protein-protein interactions using the structure of SH2-phosphopeptide complexes and the FoldX algorithm. We show that our approach performs similarly to experime...

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Bibliografiske detaljer
Main Authors: Sánchez, Ignacio E., Beltrao, Pedro, Stricher, Francois, Schymkowitz, Joost, Ferkinghoff-Borg, Jesper, Rousseau, Frederic, Serrano, Luis
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2271153/
https://ncbi.nlm.nih.gov/pubmed/18389064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000052
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