β-Globin LCR and Intron Elements Cooperate and Direct Spatial Reorganization for Gene Therapy

The Locus Control Region (LCR) requires intronic elements within β-globin transgenes to direct high level expression at all ectopic integration sites. However, these essential intronic elements cannot be transmitted through retrovirus vectors and their deletion may compromise the therapeutic potenti...

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Detalhes bibliográficos
Main Authors: Buzina, Alla, Lo, Mandy Y. M., Moffett, Angela, Hotta, Akitsu, Fussner, Eden, Bharadwaj, Rikki R., Pasceri, Peter, Garcia-Martinez, J. Victor, Bazett-Jones, David P., Ellis, James
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2271131/
https://ncbi.nlm.nih.gov/pubmed/18404216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000051
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