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Heterotypic RPE-choroidal endothelial cell contact increases choroidal endothelial cell transmigration via PI 3-kinase and Rac1

Age-related macular degeneration (AMD) is the major cause of non-preventable blindness. Severe forms of AMD involve breaching of the retinal pigment epithelial (RPE) barrier by underlying choroidal endothelial cells (CECs), followed by migration into, and subsequent neovascularization of the neurose...

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Autori principali: Peterson, Lynda J., Wittchen, Erika S., Geisen, Pete, Burridge, Keith, Hartnett, M. Elizabeth
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2270476/
https://ncbi.nlm.nih.gov/pubmed/17292356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2006.12.012
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