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Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion
AIMS/HYPOTHESIS: Insulin secretion in pancreatic islets is dependent upon mitochondrial function and production of ATP. The transcriptional coactivator peroxisome proliferator activated receptor gamma coactivator-1 alpha (protein PGC-1α; gene PPARGC1A) is a master regulator of mitochondrial genes an...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer-Verlag
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2270364/ https://ncbi.nlm.nih.gov/pubmed/18270681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-007-0916-5 |
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