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A residue in the intracellular vestibule of the pore is critical for gating and permeation in Ca(2+)-activated K(+) (BK(Ca)) channels
1. We have used patch clamp to record large-conductance Ca(2+)-activated K(+) (BK(Ca)) currents from a human embryonic kidney cell line (HEK293) expressing wild-type and mutant hSloα channels. 2. When we mutated F380 in the S6 region, thought to contribute to the intracellular vestibule of the pore,...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Blackwell Science Inc
2000
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2270189/ https://ncbi.nlm.nih.gov/pubmed/11080257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2000.00131.x |
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